Norethindrone
1. Functional groups: i. Ketone ii. Alkene iii. Alkyne iv. Alcohol
2. Uses: i. Birth control ii. To treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance
3. Misuses: i. Don’t use if you have breast cancer, liver disease, or if you are pregnant ii. Missing a pill can make the drug ineffective and cause side effects
4. Mechanism: i. Progestins diffuse freely into target cells and bind to the progesterone receptor, slow the frequency of release of gonadotropin-releasing hormone from the hypothalamus and blunt the pre-ovulatory LH surge
5. Side effects: i. Irregular vaginal bleeding or spotting, headache, breast pain or swelling, stomach pain, bloating, nausea, vomiting, hair loss, depressed mood, trouble sleeping, weight gain, vaginal itching, or discharge
6. When it was discovered: 1951
7. When it was first used: 1957
8. Which countries/groups have used it: i. It is marketed widely throughout the world
9.Still in use? i. Yes
10. Derived from: i. Progesterone
11. Approved by the FDA? i. Yes, in 2001
References:
i. https://www.drugbank.ca/drugs/DB00717
