Morphine
1. Uses and misuses:
i. An opioid used as medication to relieve moderate to severe pain.
ii. Works within the brain to change how your body feels and responds to pain.
iii. Misuse of morphine may lead to symptoms such as
​-Lowered blood pressure
-Nausea
-Confusion
2. Mechanism of action (what effect the compound has and what part of the molecule causes it to have that particular effect):
i. Morphine-6-glucuronide-the major metabolite of morphine
3. Side effects of the medication:
​-Sleepiness
​-Constipation
-Itching
4. Historical perspective of each compound (when it was discovered, first used, which groups/countries have used it and whether it is still in used today):
i. Discovered by 21-year-old pharmacist assistant, Freidrich Wilhelm Adam Serturner in the early 1800s. ii. Western Europe and North American countries consume the majority of morphine in the world in comparison to Asian, African, and Middle Eastern countries
iii. It is still in use today
5. State where the drug derived from or if it was made from a drug or isolated from a plant:
i. Originally isolated from the resinous gum secreted by the opium poppy (plant)
6. Whether or not approved by the FDA:
-Yes
References:
https://www.webmd.com/drugs/2/drug-327-819/morphine-oral/morphine-oral/details
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https://www.drugbank.ca/drugs/DB00295
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